Kenny X. F. Yang

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Protein kinase C (PKC) has been implicated in the control of airway smooth muscle (ASM) tone, and abnormalities in PKC-dependent signaling may be associated with asthma. PKC exists in different isoforms, but the pattern of their expression in ASM has not been previously reported. Accordingly, the purpose of the present study was to identify which isoforms(More)
Protein kinase C (PKC) is implicated in the regulation of smooth muscle contractility and growth. We have previously described the pattern of isoform expression of PKC in canine airway smooth muscle. This study identified the isoforms present in human cultured airway smooth muscle cells and also addressed the question of whether mitogenesis in these cells(More)
The involvement of protein kinase C in the contraction of airway smooth muscle has been investigated in human isolated bronchus. Phorbol 12,13-dibutyrate (PDB) (10 microM) produced aw biphasic response--relaxation followed by contraction. The protein kinase C inhibitor, staurosporine (0.1 microM) reduced the contractile response to PDB from 89 +/- 2.9% to(More)
OBJECTIVES The management of dual-antiplatelet therapy when patients present for surgical revascularization is a clinical challenge. Whether increasing fibrinogen levels can restore hemostasis in this context is not established but may represent increased platelet glycoprotein fibrinogen binding, altered adenosine diphosphate (ADP)-dependent platelet(More)
Carlin, Steve, Kenny X. F. Yang, Richard Donnelly and Judith L. Black. Protein kinase C isoforms in human airway smooth muscle cells: activation of PKC-z during proliferation. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L506–L512, 1999.—Protein kinase C (PKC) is implicated in the regulation of smooth muscle contractility and growth. We have(More)
Activation of protein kinase C by phorbol 12,13-dibutyrate (PDB) (1 nM-3 microM) caused a concentration-dependent contractile response in human isolated bronchus. The mean maximal contraction was 26 +/- 4.4% (n = 11) of that induced by acetylcholine (1 mM). The contraction was increased by the presence of the Ca2+ ionophore (A23187) to 47 +/- 6% (n = 7, P <(More)
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