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A linear wirelength objective more eeectively captures timing, congestion, and other global placement considerations than a squared wirelength objective. The GORDIAN-L cell placement tool 19] minimizes linear wirelength by rst approximating the linear wirelength objective by a modiied squared wirelength objective, then executing the following loop { (1)(More)
The "quadratic placement" methodology is rooted in [Module Placement Based on Resistive Network Optimization, Proud: A Sea-Of-Gate Placement Algorithm, A Combined Force and Cut Algorithm for Hierarchical VLSI Layout]and is reputedly used in many commercial and in-house tools forplacement of standard-cell and gate-array designs. The methodologyiterates(More)
PURPOSE OF REVIEW Recent advances in the role of cancer stem cells (CSCs) in glioblastoma will be reviewed. RECENT FINDINGS In the decade since the description of brain tumor CSCs, the potential significance of these cells in tumor growth, therapeutic resistance, and spread has become evident. Most recently, the interplay between CSCs, tumor genetics, and(More)
Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this disease. As in other cancers, recent studies have identified highly tumorigenic subpopulations within malignant gliomas, known generally as cancer stem cells. Here, we demonstrate that glioma stem(More)
Embedded memory blocks (EMBs) are used in modern field programmable gate arrays (FPGAs) for implementation of on-chip memories or specialized logic functions[1]. In this paper, we propose an integrated approach with structural clustering and functional decomposition to minimize the circuit area using EMBs while preserving the circuit delay. The structural(More)
Retinal amacrine cells are a diverse set of interneurons within the inner nuclear layer. The canonical Wnt pathway is highly active within mature amacrine cells, but its role remains unclear. Leucine-rich repeat containing G-protein receptor 5 (Lgr5) is a newly identified component of the Wnt receptor complex that potentiates beta-catenin signaling. In(More)
The long terminal repeat retrotransposon Tf1 of Schizosaccharomyces pombe uses a unique mechanism of self priming to initiate reverse transcription. Instead of using a tRNA, Tf1 primes minus-strand synthesis with an 11-nucleotide RNA removed from the 5' end of its own transcript. We tested whether the self primer of Tf1 was similar to tRNA primers in being(More)
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