Kenneth Thompson

Alan Gill4
Steven Perrin3
Theodore W Frick2
Fernando G. Vieira2
4Alan Gill
3Steven Perrin
2Theodore W Frick
2Fernando G. Vieira
2Beth Levine
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BACKGROUND In any animal model of human disease a positive control therapy that demonstrates efficacy in both the animal model and the human disease can validate the application of that animal model to the discovery of new therapeutics. Such a therapy has recently been reported by Fornai et al. using chronic lithium carbonate treatment and showing(More)
Treatment options for people living with amyotrophic lateral sclerosis (ALS) are limited and ineffective. Recently, dexpramipexole (RPPX) was advanced into human ALS clinical trials. In the current studies, we investigated RPPX in two parallel screening systems: 1) appropriately powered, sibling-matched, gender-balanced survival efficacy screening in(More)
The Theory of Totally Integrated Education (TIE) predicts that mental structures formed by learners are expected to be stronger when 'knowing that one', 'knowing how', and 'knowing that' are integrated with learner emotions and intentions. Such whole, completely connected mental structures are expected to be less vulnerable to forgetting. TIE theory further(More)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear. However, there is evidence for involvement of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in ALS, notably in mutant SOD1 mediated models(More)
The SOD1-G93A transgenic mouse is the most widely used animal model of amyotrophic lateral sclerosis (ALS). At ALS TDI we developed a phenotypic screening protocol, demonstrated in video herein, which reliably assesses the neuromuscular function of SOD1-G93A mice in a quick manner. This protocol encompasses a simple neurological scoring system (NeuroScore)(More)
Map & Analyze Patterns & Structures Across Time (MAPSAT) is a new set of mapping tools that are appropriate for analyses of system dynamics and structure in education. MAPSAT consists of two complementary methodologies: Analysis of Patterns in Time (APT) and Analysis of Patterns in Configuration (APC). In APT, a researcher creates temporal maps by observing(More)
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