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Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
TLDR
It is demonstrated that EAA stimulate MPS independently of increased insulin availability, and in the elderly, a deficit in MPS in the basal state is unlikely; and the decreased sensitivity and responsiveness of MPS to EAA, associated with decrements in the expression and activation of components of anabolic signaling pathways, are probably major contributors to the failure of muscle maintenance inThe elderly. Expand
Acute skeletal muscle wasting in critical illness.
TLDR
A comprehensive prospective characterization of skeletal muscle wasting, defining the pathogenic roles of altered protein synthesis and breakdown was performed and skeletal muscle loss was determined through serial ultrasound measurement. Expand
Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men
TLDR
In the post‐absorptive state, MPS is dose dependant on intensity rising to a plateau at 60–90% 1 repetition maximum (1 RM), and older men show anabolic resistance of signalling and MPS to resistance exercise. Expand
Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise.
TLDR
A 20-g dose of whey protein is sufficient for the maximal stimulation of postabsorptive rates of myofibrillar MPS in rested and exercised muscle of ~80-kg resistance-trained, young men. Expand
Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise
TLDR
There is a rapid increase in collagen synthesis after strenuous exercise in human tendon and muscle, and the similar time course of changes of protein synthetic rates in different cell types supports the idea of coordinated musculotendinous adaptation. Expand
Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion
TLDR
It is confirmed that 14 days of immobilization reduces MPS in the post‐absorptive state and this diminution is reduced but not abolished by increased provision of AA, even at high rates. Expand
Human muscle protein synthesis and breakdown during and after exercise.
TLDR
There appear to be few, if any, differences in the response of young women and young men to acute exercise, although there are indications that, in older women, the responses may be blunted more than in older men. Expand
Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions.
TLDR
A more rapid rise in MPS after maximal LC could translate into greater protein accretion and muscle hypertrophy during chronic resistance training utilizing maximal LC. Expand
A validation of the application of D(2)O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.
TLDR
D2O has unrivaled utility to quantify day-to-day MPS in humans and inform on short-term changes in anabolism and presumably catabolism alike. Expand
Molecular Networks of Human Muscle Adaptation to Exercise and Age
TLDR
It is concluded that human muscle age-related molecular processes appear distinct from the processes regulated by those of physical activity, as ATRA and AhR gene-sets appear to represent “generic” physical activity responsive gene-networks. Expand
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