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Traffic jam at the bacterial sec translocase: targeting the SecA nanomotor by small-molecule inhibitors.
The rapid rise of drug-resistant bacteria is one of the most serious unmet medical needs facing the world. Despite this increasing problem of antibiotic resistance, the number of differentExpand
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Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening
The rapid rise of antibiotic-resistant bacteria is one of the major concerns in modern medicine. Therefore, to treat bacterial infections, there is an urgent need for new antibacterials–preferablyExpand
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Cell‐Free Expression of G Protein–Coupled Receptors
The large‐scale production of recombinant G protein–coupled receptors (GPCRs) is one of the major bottlenecks that hamper functional and structural studies of this important class of integralExpand
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Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors.
An efficient synthesis of a library of 5-amino-thiazolo[4,5-d]pyrimidines is reported. Regioselective displacements of chlorines, as well as regioselective diazotation reactions are described, whichExpand
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Development of a high-throughput screening assay for the discovery of small-molecule SecA inhibitors.
A major pathway for bacterial preprotein translocation is provided by the Sec-dependent preprotein translocation pathway. Proteins destined for Sec-dependent translocation are synthesized asExpand
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Synthesis and Antibacterial Evaluation of a Novel Series of 2‐(1,2‐Dihydro‐3‐oxo‐3H‐pyrazol‐2‐yl)benzothiazoles
The 2‐(1,2‐dihydro‐3‐oxo‐3H‐pyrazol‐2‐yl)benzothiazole scaffold was selected as a central core structure for the discovery of novel antibacterial compounds. A systematic variation of the substituentsExpand
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