Kenneth S. Yew

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Mutations in the DJ-1 gene have been described in autosomal recessive Parkinson's disease patients (ARPD) of European ancestry and young onset (YOPD) Ashkenazi Jewish and Afro-Caribbean patients. There is little information on the prevalence of DJ-1 mutations amongst Asian PD populations. In this study, we examined for DJ-1 mutations in consecutive YOPD and(More)
BACKGROUND The synaptic cell adhesion molecules, protocadherins, are a vertebrate innovation that accompanied the emergence of the neural tube and the elaborate central nervous system. In mammals, the protocadherins are encoded by three closely-linked clusters (alpha, beta and gamma) of tandem genes and are hypothesized to provide a molecular code for(More)
The MDR1 multidrug transporter is important in regulating environmental xenobiotics and hence may play a causative role in Parkinson's disease (PD). MDR1 haplotype comprising 2677 G > T/A and 3435 C > T may be protective against PD. Using a case control methodology, we investigated the association of MDR1 haplotypes (single nucleotide polymorphisms (SNPs)(More)
Pyridoxal-5-phosphate, the biological active form of pyridoxine, is a cofactor for dopa-decarboxylase (DDC) enzyme. Pyridoxine may augment the conversion of levodopa to dopamine in the periphery and therefore decrease availability of levodopa to the brain. However, this effect can be negated in the presence of a DDC inhibitor, which potentiates plasma(More)
PURPOSE Clinicians are overwhelmed by the sheer magnitude of new clinical information that is available on a daily basis. Despite the availability of information tools for finding this information and for updating clinical knowledge, no study has examined the quality of current information alerting services. METHODS We developed a 7-item checklist based(More)
BACKGROUND AND OBJECTIVES The long-term effect of teaching critical appraisal (CA) and evidence-based medicine (EBM) skills is unknown. This study explores long-term behaviors and learner satisfaction after a 3-year longitudinal CA/EBM curriculum. METHODS Telephone interviews were conducted with 1996-1998 graduates of an academic family medicine residency(More)
  • Chen How Wong, Wei Zhan, Renee Siew, Yin Ka, Tung Chin, Kenneth Yew +2 others
  • 2014
— Collaborative beamforming (CB) is an idea where beamforming concept is used to establish link in wireless sensor networks (WSNs). Via CB, a subset number of nodes from a network of sensors are able to transmit a common message over long communication distance in a more energy efficient manner. Due to erratic deployment of the sensor nodes in the networks,(More)
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