Kenneth R. Cote

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The ability of transcutaneous recordings of gastric electrical activity to detect gastric electrical abnormalities was determined by simultaneous measurements of gastric electrical activity with surgically implanted serosal electrodes and cutaneous electrodes in six patients undergoing abdominal operations. Transient abnormalities in gastric electrical(More)
Forty-four severely constipated women and 16 (8 female, 8 male) asymptomatic volunteers underwent assessment of colon function by (a) clinical examination, (b) rectosigmoid intraluminal pressure recording, (c) colonic transit utilizing radiopaque markers, (d) anorectal manometry, and (e) rectosigmoid electrical activity. Constipated patients were(More)
The length dependence of the spontaneous contractile activity of human colonic muscle was assessed in vitro. Muscle obtained from the right colon was more distensible than that of the left colon. This was true for all muscle layers. Maximum spontaneous active stress was exerted by both circular and longitudinal muscle layers of the right colon at greater(More)
Extracellular electrical activity was measured in vitro in 28 specimens of human colon taken at the time of operation. The mucosa was removed, and the muscle strips were mounted in an organ bath irrigated with oxygenated Krebs. Records were made from 3-7 silver/silver chloride electrodes placed directly on the circular muscle, for periods of 15-30 min. Data(More)
Extracellular electrical and contractile activities were recorded in vitro from strips of human colonic smooth muscle obtained at the time of surgery. Serosal electrical activity of longitudinally oriented strips from the taenia and intertaenial region was characterised by continuous oscillation at a frequency of 28 +/- 1/min. Contractions were marked(More)
Silver/silver chloride (Ag/AgCl) electrodes possess excellent electrical properties for measuring the electrical activity of gastrointestinal smooth muscle but exert toxic effects on this tissue in vitro. We thus developed a platinum electrode for use in vitro, the construction of these electrodes relying upon the formation of a glass-platinum/iridium seal.(More)
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