Kenneth Miles

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  • K A Miles
  • The British journal of radiology
  • 1991
A method for quantifying tissue perfusion by dynamic computed tomography (CT) is described. By applying a nuclear medicine data processing technique to time-density data from a single-location dynamic CT sequence, tissue perfusion can be determined from the maximum gradient of the tissue time-density curve divided by the peak enhancement of the aorta. Using(More)
  • K A Miles
  • The British journal of radiology
  • 2003
Perfusion CT is a technique that can be readily incorporated into the existing CT protocols that continue to provide the mainstay for anatomical imaging in oncology to provide an in vivo marker of tumour angiogenesis. By capturing physiological information reflecting the tumour vasculature, perfusion CT can be useful for diagnosis, risk-stratification and(More)
PURPOSE To determine if computed tomographic (CT) texture features of primary colorectal cancer are related to 5-year overall survival rate. MATERIALS AND METHODS Institutional review board waiver was obtained for this retrospective analysis. Texture features of the entire primary tumor were assessed with contrast material-enhanced staging CT studies(More)
Angiogenesis describes the formation of new blood vessels within tumours. The process is essential for tumour growth and metastasis. The development of new vessels leads to physiological changes, specifically increased perfusion, blood volume and capillary permeability, that alter contrast enhancement during computed tomography (CT). Functional CT(More)
BACKGROUND Tumor spatial heterogeneity is an important prognostic factor, which may be reflected in medical images METHODS Image texture analysis is an approach of quantifying heterogeneity that may not be appreciated by the naked eye. Different methods can be applied including statistical-, model-, and transform-based methods. RESULTS Early evidence(More)
PURPOSE To assess changes in tumor computed tomographic (CT) texture after two cycles of treatment with tyrosine kinase inhibitors (TKIs) and to determine if tumor texture correlates with measured time to progression in patients with metastatic renal cell cancer who received TKIs. MATERIALS AND METHODS A waiver of institutional review board approval was(More)
AIM To undertake a pilot study assessing whether tumour heterogeneity evaluated using computed tomography texture analysis (CTTA) has the potential to provide a marker of tumour aggression and prognosis in oesophageal cancer. MATERIALS AND METHODS In 21 patients, unenhanced CT images of the primary oesophageal lesion obtained using positron-emission(More)
The standardized enhancement value and standardized perfusion value allow comparison between different methods for quantification of contrast enhancement during computed tomography (CT). Standard perfusion values calculated from CT measurements of perfusion within pulmonary nodules compared favorably with those derived from previously reported enhancement(More)
Functional Computed Tomography (CT) describes the use of existing technologies and conventional contrast agents to capture physiological parameters that reflect the vasculature within tumours and other tissues. The technique is readily incorporated into routine conventional CT examinations and, in tumours, the physiological parameters obtained provide an(More)