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We describe a new application for imaging with computed tomography (CT) in which a quantifiable map of tissue perfusion is created and displayed by means of a colour scale. A rapid sequence of images is acquired without table movement immediately after a bolus intravenous injection of radiographic contrast medium. The rate of enhancement in each pixel(More)
PURPOSE To determine if computed tomographic (CT) texture features of primary colorectal cancer are related to 5-year overall survival rate. MATERIALS AND METHODS Institutional review board waiver was obtained for this retrospective analysis. Texture features of the entire primary tumor were assessed with contrast material-enhanced staging CT studies(More)
BACKGROUND Tumor spatial heterogeneity is an important prognostic factor, which may be reflected in medical images METHODS Image texture analysis is an approach of quantifying heterogeneity that may not be appreciated by the naked eye. Different methods can be applied including statistical-, model-, and transform-based methods. RESULTS Early evidence(More)
The aim was to undertake an initial study of the relationship between texture features in computed tomography (CT) images of non-small cell lung cancer (NSCLC) and tumour glucose metabolism and stage. This retrospective pilot study comprised 17 patients with 18 pathologically confirmed NSCLC. Non-contrast-enhanced CT images of the primary pulmonary lesions(More)
Primary progressive aphasia (PPA) is defined as progressive decline in language for 2 or more years with preservation of activities of daily living and general cognitive functions. Whereas the clinical features of this syndrome have been well documented, the neuroradiological findings have not been studied systematically. We studied 13 patients with PPA(More)
Assessment of quantitative cerebral blood flow on a conventional fast CT machine without the use of specialized equipment may be valuable in the investigation of acute stroke and head injury. We aimed to compare a single slice CT perfusion sequence with H2(15)O positron emission tomography using the sagittal sinus as an input function, a method that avoids(More)
OBJECTIVES Three-dimensional (3-D) selective- and relative-scale texture analysis (TA) was applied to structural magnetic resonance (MR) brain images to quantify the presence of grey-matter (GM) and white-matter (WM) textural abnormalities associated with schizophrenia. MATERIALS AND METHODS Brain TA comprised volume filtration using the Laplacian of(More)
The ability to demonstrate tumour foci that are undetected by conventional imaging has resulted in the emergence of positron emission tomography (PET) as a valuable clinical tool in oncology. This article describes the technique and indications for fluorine-18 labelled fluorodeoxyglucose (18 FDG)-PET in lung cancer, demonstrating the high accuracy and(More)
Heterogeneity is a key feature of malignancy associated with adverse tumour biology. Quantifying heterogeneity could provide a useful non-invasive imaging biomarker. Heterogeneity on computed tomography (CT) can be quantified using texture analysis which extracts spatial information from CT images (unenhanced, contrast-enhanced and derived images such as CT(More)
The standardized uptake value (SUV) and other measurements of tumour uptake of fluorodeoxyglucose (FDG) on positron emission tomography (PET) can potentially be supplemented by additional imaging parameters derived either from the PET images or from the computed tomography (CT) component of integrated PET/CT examinations including tumour size, CT(More)