Kenneth Laurence Kennedy

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BACKGROUND Oxidative stress following hemorrhagic shock and resuscitation (HSR) is regulated, in part, by inflammatory and apoptotic mediators such as necrosis factor κB (NF-κB) and p53. Sirtuin 1 (Sirt-1) is a metabolic intermediary that regulates stress responses by suppressing NF-κB and p53 activity. Resveratrol is a naturally occurring polyphenolic(More)
Phencyclidine reliably disrupts prepulse inhibition of the acoustic startle response in rats. Previous research has suggested that atypical antipsychotics (e.g., those that do not produce extrapyramidal motor effects) attenuate the disruptive effects of phencyclidine in this model whereas typical antipsychotics do not. Nearly all of this research has used(More)
OBJECTIVE To determine fungal allergen reactivity prevalence by intradermal dilutional testing in patients with and without chronic rhinitis or rhinosinusitis symptoms. STUDY DESIGN Prospective comparison of fungal allergen reactivity prevalence in symptomatic and asymptomatic patients. SETTING University medical center. METHODS Group I (chronic(More)
BACKGROUND Oxidative stress associated with hemorrhagic shock and reperfusion (HSR) results in the production of superoxide radicals and other reactive oxygen species, leading to cell damage and multiple-organ dysfunction. We sought to determine if MitoQ, a mitochondria-targeted antioxidant, reduces morbidity in a rat model of HSR by limiting oxidative(More)
Kaposi sarcoma (KS) is a soft-tissue malignancy arising from the proliferation of spindle cells with vascular endothelial cell origin. The disease most frequently affects mucocutaneous tissues as well as the visceral aerodigestive tract. Lesions can arise anywhere along the digestive tract from the oral cavity to the perianal region. Human herpesvirus 8(More)
OBJECTIVES To review the management and outcomes of pediatric patients treated for descending mediastinitis at a single institution and contribute to an updated mortality rate. STUDY DESIGN Case series with chart review. SETTING Tertiary care pediatric hospital. SUBJECTS AND METHODS This study is a 19-patient case series of all patients treated for(More)
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