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Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" postulated to establish a naive ground state. We show that the transcriptome and epigenome profiles of serum- and(More)
This is an application of new longitudinal structural equation modeling techniques to time-dependent associations of memory and brain structure measurements. There were 225 participants aged 30-80 years at baseline who were measured again after a 7-year interval on both the lateral ventricular size and Wechsler memory score. Multiple regression analyses(More)
Puerarin and daidzin are the major isoflavone glucosides found in kudzu dietary supplements. In this study, we demonstrated that puerarin significantly improves glucose tolerance in C57BL/6J-ob/ob mice, an animal model of type 2 diabetes mellitus, blunting the rise in blood glucose levels after i.p. administration of glucose. In contrast, daidzin, the(More)
The Modern Portfolio Theory of Markowitz maximized portfolio expected return subject to holding total portfolio variance below a selected level. Digital Portfolio Theory is an extension of Modern Portfolio Theory, with the added dimension of memory. Digital Portfolio Theory decomposes the portfolio variance into independent components using the signal(More)
  • C H I L D R E N, Y O U T H A N D F A M I L Y S E R V I C E S, Jacquelyn Shipp, Training, Ta Coordinator, Keith Pirtle +23 others
  • 2009
This Toolkit is intended to be used as a guide for development of new SOC communities as well as for existing sites as a reference guide. You are welcome to use these materials as appropriate for your location. Please reference the ‚Oklahoma Systems of Care Toolkit‛ when using the material in other publications. Website addresses are outlined on page 126.(More)
Obese women exhibit decreased fertility, high miscarriage rates and dysfunctional corpus luteum (CL), but molecular mechanisms are poorly defined. We hypothesized that weight gain induces alterations in CL gene expression. RNA sequencing was used to identify changes in the CL transcriptome in the vervet monkey (Chlorocebus aethiops) during weight gain. 10(More)
Joint MiRNA/mRNA expression profiling reveals rhanges consistent with development of dysfunctional corpus luteum after weight gain. Abstract Obese women exhibit decreased fertility, high miscarriage rates and dysfunctional corpus luteum (CL), but molecular mechanisms are poorly defined. We hypothesized that weight gain induces alterations in CL gene(More)
D o you ever wonder why the term " evaluation " is such a common word among so many organizations these days? This is due in part to the heightened level of accountability that has moved beyond expectation to obligation. Believing that evaluation focuses solely on a large number of people simply participating in a program is a thing of the past. Most(More)