Kenneth J Shea

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BACKGROUND Hearing impairment is 1 of the 4 most prevalent chronic conditions in the elderly. However, the biological basis of age-related hearing loss is unknown. OBJECTIVE The objective was to test the hypothesis that age-related hearing loss may be associated with poor vitamin B-12 and folate status. DESIGN A thorough audiometric assessment was(More)
The behaviour of water in nanopores is very different from that of bulk water. Close to hydrophobic surfaces, the water density has been found to be lower than in the bulk, and if confined in a sufficiently narrow hydrophobic nanopore, water can spontaneously evaporate. Molecular dynamics simulations have suggested that a nanopore can be switched between(More)
Social insects maintain colony cohesion by recognizing and, if necessary, discriminating against conspecifics that are not part of the colony. This recognition ability is encoded by a complex mixture of cuticular hydrocarbons (CHCs), although it is largely unclear how social insects interpret such a multifaceted signal. CHC profiles often contain several(More)
A novel method for preparation of biomacromolecular imprinted nanoparticles is described. Combinations of functional monomers were polymerized in the presence of the imprinting peptide melittin in aqueous solution at room temperature to produce a small library of polymer nanoparticles. The template peptide and unreacted monomers are subsequently removed by(More)
Synthetic polymer nanoparticles with antibody-like affinity for a hydrophilic peptide have been prepared by inverse microemulsion polymerization. Peptide affinity was achieved in part by incorporating the target (imprint) peptide in the polymerization reaction mixture. Incorporation of the imprint peptide assists in the creation of complementary binding(More)
Ischemic stroke in a 12-year-old African-American boy was caused by intracranial fibromuscular dysplasia. Imaging investigations included computed tomography and magnetic resonance angiography, before reaching a definitive diagnosis with a conventional cerebral angiogram. This pediatric case of intracranial fibromuscular dysplasia highlights the need to(More)
Mobile phase effects were studied in the separation of D- and L-phenylalanine anilide (D,L-PA) on an imprinted chiral stationary phase (CSP). Using an aqueous-organic mobile phase, an improved column performance was seen, reflected in a two-fold decrease in the reduced plate height and an almost doubling of the resolution as compared to when a pure organic(More)
Although carotid and vertebral (cervical) arterial dissections are not common presentations to the emergency department, timely and appropriate diagnostic strategies will allow early initiation of effective treatment therapies. Cervical arterial dissection occurs when the intimal wall of an artery is damaged as a result of trauma or defect. As blood fills(More)