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BACKGROUND Estrogen receptor positive (ER+) breast cancers (BC) are heterogeneous with regard to their clinical behavior and response to therapies. The ER is currently the best predictor of response to the anti-estrogen agent tamoxifen, yet up to 30-40% of ER+BC will relapse despite tamoxifen treatment. New prognostic biomarkers and further biological(More)
Tumor grade is an established indicator of breast cancer outcome, although considerable heterogeneity exists even within-grade. Around 25% of grade III invasive ductal breast carcinomas are associated with a "basal" phenotype, and these tumors are reported to be a distinct subgroup. We have investigated whether this group of breast cancers has a(More)
  • Susan Houseman, W. E. Upjohn, +7 authors Robert Yuskavage
  • 2007
I discuss reasons why manufacturing productivity statistics should be interpreted with caution in light of the recent growth of domestic and foreign outsourcing and offshoring. First, outsourcing and offshoring are poorly measured in U.S. statistics, and poor measurement may impart a significant bias to manufacturing and, where offshoring is involved,(More)
INTRODUCTION Cytokeratin (CK) 14, one of several markers expressed in normal myoepithelial/basal cells, is also expressed in a proportion of breast carcinomas. Previous studies have suggested that expression of such 'basal' markers predicts different biological behaviour, with more frequent lung and brain metastases and poorer prognosis than other(More)
CUTL1, also known as CDP, Cut, or Cux-1, is a homeodomain transcriptional regulator known to be involved in development and cell cycle progression. Here we report that CUTL1 activity is associated with increased migration and invasiveness in numerous tumor cell lines, both in vitro and in vivo. Furthermore, we identify CUTL1 as a transcriptional target of(More)
BACKGROUND Given the large number of genes purported to be prognostic for breast cancer, it would be optimal if the genes identified are not confounded by the continuously changing systemic therapies. The aim of this study was to discover and validate a breast cancer prognostic expression signature for distant metastasis in untreated, early stage, lymph(More)
The significance of occult metastases in axillary lymph nodes in patients with carcinoma of the breast is controversial. Additional sections were cut from the axillary lymph nodes of 477 women with invasive carcinoma of the breast, in whom no metastases were seen on initial assessment of haematoxylin and eosin stained sections of the nodes. One section was(More)
The 2007 Economic Census asked establishments to identify if they engaged in domestic outsourcing or foreign offshoring for manufacturing and wholesaling. These novel data can be linked to existing longitudinal business microdata that include information on such variables as employment, firm structure and revenue. In this paper, we describe the collected(More)
FOREWORD The rapid pace of globalization poses significant challenges and opportunities for the U.S. economy and its workforce. The opportunities for economic growth and prosperity presented by increased trade are well known. So too are the challenges for businesses and workers, who must adjust as the location of specific economic activities among trading(More)
FOREWORD The rapid pace of globalization poses significant challenges and opportunities for the U.S. economy and its workforce. The opportunities for economic growth and prosperity presented by increased trade are well known. So too are the challenges for businesses and workers, who must adjust as the location of specific economic activities among trading(More)