Kenneth D. Bagshawe

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PURPOSE To evaluate the results of etoposide, methotrexate, and dactinomycin alternating with cyclophosphamide and vincristine (EMA/CO) chemotherapy in women with high-risk gestational trophoblastic tumors (GTT) and to document the middle- and long-term toxicity of the regimen. PATIENTS AND METHODS A total of 272 consecutive women with high-risk GTT,(More)
Within a few years of the beginnings of cancer chemotherapy anticancer prodrugs were being synthesised. A series of azo mustards was designed and produced by Ross and Warwick (1955) at the Chester Beatty Research Institute so that under in vivo conditions the azo link would be cleaved by enzymes and agents with powerful alkylating activity would be(More)
Measurements of HCG and carcino-embryonic antigen (CEA) were made in 26 patients with ovarian cancer to evaluate these substances as tumour markers; 13-4 per cent of 194 CEA estimations and 14-6 per cent of 144 HCG estimations were abnormal. CEA values were abnormal in 9 out of 26 patients and HCG values in 13 out of 26 patients. The implications of these(More)
Antibody-directed enzyme prodrug therapy (ADEPT) has been studied in a human ovarian carcinoma xenograft grown subcutaneously in nude mice. Radioimmunoassay of supernatants obtained from tumor homogenates showed these to contain carcinoembryonic antigen (CEA). Biodistribution studies with125I-labeled monoclonal anti-CEA antibody, A5B7, and its F(ab′)2(More)
The development of targeted therapy requires that the concentration of the therapeutic agent can be estimated in target and normal tissues. Single photon emission tomography (SPET), with and without scatter correction, and planar imaging using131I have been compared to develop a method for investigation of targeted therapy. Compton scatter was investigated(More)
Two hundred and two patients with gestational trophoblastic tumours (GTT) were treated using single agent etoposide. Patients were divided into low, medium and high risk groups using a prognostic index. Initial chemotherapy commenced with etoposide in 101 patients and 94 were accessible. Partial response (PR), defined by a log fall in serum human chorionic(More)
Between 1957 and February 1981, 782 patients received cytotoxic chemotherapy for gestational trophoblastic tumors (GTT) in the Department of Medical Oncology, Charing Cross Hospital (London, England). Sixty-nine (8.8%) patients had central nervous system (CNS) metastases. Thirty-three of them (48%) presented with CNS disease prior to treatment (CNS(More)
Of 297 patients with metastatic testicular and extragonadal germ cell tumours (GCT), bone involvement was detected clinically in 3% (7/251) of those at first presentation and in 9% (4/46) of relapsed cases. This difference was not statistically significant (95% confidence limits -2%; +14%). Concurrent systemic metastases, commonly involving lung (7/11(More)