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C1q is the target recognition protein of the classical complement pathway and a major connecting link between innate and acquired immunity. As a charge pattern recognition molecule of innate… (More)
C1q is a versatile innate immune molecule that serves as the initiation subcomponent of the classical complement pathway. In addition, it is also a potent pattern recognition molecule, the… (More)
cDNA and genomic clones are now available for nearly 30 glycoproteins which comprise the components, regulatory proteins, and receptors associ ated with the complement system (Figure 1 , Table 1).… (More)
The primary sequences of nearly all the proteins associated with the complement system have now been established (Reid, 1986; Campbell et al., 1988). The majority of these proteins are mosaic in… (More)
CRP and the mammalian lectins containing collagen-like structure (collectins) can clearly participate in a variety of antibody-independent recognition and clearance mechanisms which result in the… (More)
SIR,-Severe hypoglycaemia is a feared complication of diabetes mellitus. Signs of hypoglycaemia are essential to recognise a fall in blood glucose. Dr Heller and colleagues (Aug 15, p 359) assessed… (More)
Clq is the non-enzymatic recognition subcomponent of C1, the first component of the classical pathway of the human complement system. It is a M r 460 glycoprotein composed of 18 polypeptide chains of… (More)
Most of the proteins and receptors associated with the activation and control of the complement system have now been cloned at both the cDNA and genomic levels and chromosome assignments are… (More)
Using cDNA probes for Factor H (FH) and C4 binding protein (C4BP) on a panel of somatic cell hybrids, we show that both of these genes map to the long arm of chromosome 1.