Kenneth Andrew Sikaris

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De Ritis described the ratio between the serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) almost 50 years ago. While initially described as a characteristic of acute viral hepatitis where ALT was usually higher than AST, other authors have subsequently found it useful in alcoholic hepatitis, where AST is usually higher than ALT.(More)
OBJECTIVE Vitamin D deficiency is recognized as a global public health problem, but the population-based prevalence of deficiency and its determinants in Australian adults is not known. This study evaluated the vitamin D status of Australian adults aged ≥25 years and risk factors associated with vitamin D deficiency in this population. DESIGN AND PATIENTS(More)
AIM To determine whether glycated haemoglobin (HbA(1c)) can be used in combination with fasting plasma glucose (FPG) for the diagnosis of diabetes in patients with impaired fasting glucose (IFG) and in a broader spectrum of patients. METHODS An algorithm was derived from oral glucose tolerance test (OGTT) capillary samples in 500 consecutive UK patients(More)
CONTEXT Serum 25-hydroxyvitamin D [25(OH)D] concentration has been inversely associated with the prevalence of metabolic syndrome (MetS), but the relationship between 25(OH)D and incident MetS remains unclear. OBJECTIVE We evaluated the prospective association between 25(OH)D, MetS, and its components in a large population-based cohort of adults aged 25(More)
OBJECTIVE To evaluate A1C for screening and diagnosis of undiagnosed type 2 diabetes defined by oral glucose tolerance testing in clinical and general populations. RESEARCH DESIGN AND METHODS A1C cut offs (< or =5.5% to rule out diabetes; > or =7.0% to rule in diabetes) were derived from a clinical group (Melbourne Pathology [MP] group: n = 2,494;(More)
Obesity is essentially an excessive accumulation of triacylglycerols in fatty tissue that is the net result of excessive energy intake compared to energy usage. Severe forms of the disease are most likely to have a predominantly genetic basis and this is probably polygenic. The 'thrifty gene' hypothesis also describes the disturbance that a modern(More)
OBJECTIVES To examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, insulin secretion, β-cell function, inflammation and metabolic markers. DESIGN 6-month randomized, placebo-controlled trial. PARTICIPANTS Ninety-five adults with serum 25-hydroxyvitamin D [25(OH)D] ≤55 nmol/L at risk of type 2 diabetes (with(More)
RESEARCHDESIGNANDMETHODS—A total of 6,537 of the 11,247 adults evaluated in 1999–2000 in the AustralianDiabetes, Obesity and Lifestyle (AusDiab) study, returned for oral glucose tolerance test (OGTT) in 2004–2005. We studied those without diabetes who had complete data at baseline (n = 5,200; mean age 51 years; 55%were women; 92%were Europids). Serum 25OHD(More)