Kenneth A. Koeplinger

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To develop a tool based on siRNA-mediated knockdown of hepatic P450 oxidoreductase (POR) to decrease the CYP-mediated metabolism of small molecule drugs that suffer from rapid metabolism in vivo, with the aim of improving plasma exposure of these drugs. siRNA against the POR gene was delivered using lipid nanoparticles (LNPs) into rats. The time course of(More)
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