Learn More
BACKGROUND Arterial distensibility measures, generally from pulse-wave velocity (PWV), are widely used with little knowledge of relationships to patient outcome. We tested whether aortic PWV predicts cardiovascular and all-cause mortality in type 2 diabetes and glucose-tolerance-tested (GTT) multiethnic population samples. METHODS AND RESULTS Participants(More)
BACKGROUND Different blood pressure (BP)-lowering drugs could have different effects on central aortic pressures and thus cardiovascular outcome despite similar effects on brachial BP. The Conduit Artery Function Evaluation (CAFE) study, a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), examined the impact of 2 different BP(More)
OBJECTIVES This paper sought to evaluate whether high sensitivity troponin (hs-cTnT) can immediately exclude acute myocardial infarction (AMI) at a novel 'rule out' cut-off. BACKGROUND Subgroup analysis of recent evidence suggests that undetectable hs-cTnT may exclude AMI at presentation. METHODS In a cohort study, we prospectively enrolled patients(More)
Cardiotrophin 1 (CT-1), a cytokine belonging to the interleukin 6 family, is increased in hypertension and in heart failure. We aimed to study the precise role of CT-1 on cardiac, vascular, and renal function; morphology; and remodeling in early stages without hypertension. CT-1 (20 μg/kg per day) or vehicle was administrated to Wistar rats for 6 weeks.(More)
Evidence supporting a role of the dendritic cell (DC) in stimulating autologous T cell activity in tropical spastic paraparesis (TSP) was sought by studies of cells taken from healthy volunteers and exposed to HTLV-1 in vitro. DC were co-cultured with an HTLV-1-producing cell line (MT-2) at 1:1 or 10:1 ratios. These DC stimulated high levels of(More)
OBJECTIVES To report nutrient intakes for three different ethnic groups living in inner city Manchester and explore under-reporting in each group. DESIGN Cross-sectional survey. All participants completed one of three food frequency questionnaires, specifically developed for each ethnic group, and took part in a larger international survey of risk factors(More)
PRIMARY OBJECTIVE To provide nutritional composition of 34 composite dishes commonly consumed in Cameroon, in order to enable dietary intake to be calculated from a Quantitative Food Frequency Questionnaire developed specifically for this population to determine associations between diet and diabetes. METHODS AND PROCEDURES A total of 197 recipes were(More)
OBJECTIVE To compare the prevalence of type 2 diabetes in white Europeans and individuals of African-Caribbean and Pakistani descent. RESEARCH DESIGN AND METHODS Random sampling of population-based registers in inner-city Manchester, Britain's third most impoverished area. A total of 1,318 people (25-79 years of age) were screened (minimum response 67%);(More)
OBJECTIVE Measurement of serum testosterone is an integral part of the assessment of men presenting to endocrine clinics. Little is known about the variation of total bound or bioavailable testosterone by ethnic group. The principal determinant of testosterone bioavailability is SHBG, which itself is a marker for insulin sensitivity. Our aim was to examine(More)
OBJECTIVE To examine the risk of stroke in relation to quality of hypertension control in routine general practice across an entire health district. DESIGN Population based matched case-control study. SETTING East Lancashire Health District with a participating population of 388,821 aged < or = 80. SUBJECTS Cases were patients under 80 with their(More)