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BACKGROUND Pulmonary cachexia is common in advanced chronic obstructive pulmonary disease (COPD), culminating in exercise intolerance and a poor prognosis. Ghrelin is a novel growth hormone (GH)-releasing peptide with GH-independent effects. The efficacy and safety of adding ghrelin to pulmonary rehabilitation (PR) in cachectic COPD patients were(More)
The protein p130 was isolated from rat brain as an inositol 1,4,5-trisphosphate-binding protein with a domain organization similar to that of phospholipase C-delta1 but lacking PLC activity. We show that p130 plays an important role in signaling by the type A receptor for gamma-aminobutyric acid (GABA). Yeast twohybrid screening identified GABARAP (GABA(A)(More)
We report that a proper employment of MWEs concerned enables us to put forth a tractable framework, which is based on a multiple nesting of semantic operations, for the processing of non-inferential, Non-propositional Contents (NPCs) of natural Japanese sentences. Our framework is characterized by its broad syntactic and semantic coverage, enabling us to(More)
It is important for future NLP systems to formulate the semantic equivalence (and more generally, the semantic similarity) of natural language expressions. In particular, paraphrasing, full text information retrieval, example-based MT and document compression technology require the effective equivalence criterion for linguistic expressions. In this paper,(More)
BACKGROUND The aim of this substudy of the ghrelin treatment, multicenter, randomized, double-blind, placebo-controlled trial was to investigate the effects of ghrelin administration on exercise capacity and the underlying mechanisms in underweight patients with chronic obstructive pulmonary disease (COPD) using cardiopulmonary exercise testing. METHODS(More)
This paper I)roI)oses two new methods to identify the correct meaning of Japanese honmnyms in text based on tile iloun:verb co-occIlrrenc(~, ill a sentence which (:an be obtained easily from corpora. The first method uses the near co-occurrence data sets, which are constructed from the above (:o-occurrence relation, to select the most fe~Lsible word among(More)
abstract Word processors or computers used in Japan employ Japanese input method through keyboard stroke combined with Kana (phonetic) character to Kanji (ideographic, Chinese) character conversion technology. The key factor of Kana-to-Kanji conversion technology is how to raise the accuracy of the conversion through the homophone processing, since we have(More)
TAKE-HOME SUMMARY Personalized pulmonary rehabilitation including occupational therapy improves the prognosis of patients with advanced COPD. PURPOSE We previously reported that patients with chronic obstructive pulmonary disease (COPD) exhibit three exercise-induced life-threatening conditions: hypoxemia, sympathetic overactivity, and respiratory(More)