Kenji Yoshida

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Semaphorins are a family of secreted and membrane-bound proteins known as axonal pathfinders. Sema4A, a member of class 4 semaphorins, induces growth cone collapse of hippocampal neurons. The binding of Sema4A to growth cones indicates the presence of receptors transmitting signals through the intracellular effectors to induce growth cone collapse in(More)
This paper describes a resistance calculation program for a layout verification system called EMAP. A new resistance calculation algorithm, based on the finite-element method, and a generalized resistor model, used in this program, are discussed. Contact resistance effects, pinch resistors, and other kinds of resistance appearing in LSI's are considered in(More)
Chromatin structure is a fundamental component of gene regulation, expression, and cellular differentiation. We have previously reported that the multifunctional coactivator p300 is a member of the Sox9 (Sry-type high mobility group box 9)-related transcriptional apparatus and activates Sox9-dependent transcription during chondrogenesis. However, the(More)
The cancer stem cell (CSC) concept has been proposed as an attractive theory to explain cancer development, and CSCs themselves have been considered as targets for the development of diagnostics and therapeutics. However, many unanswered questions concerning the existence of slow cycling/quiescent, drug-resistant CSCs remain. Here we report the(More)
BACKGROUND AND PURPOSE Cerebral hyperperfusion syndrome is a rare but serious complication of carotid endarterectomy (CEA). The aim of the present study was to determine whether intraoperative blood flow velocity (BFV) monitoring in the middle cerebral artery (MCA) by using transcranial Doppler ultrasonography (TCD) could be used as a reliable technique to(More)
BACKGROUND We previously identified unsaturated (16:1, 18:1, and 18:2) but not saturated (12:0, 14:0, 16:0, and 18:0) lysophosphatidic acids (LPAs) as potent factors for vascular smooth muscle cell (VSMC) dedifferentiation. Unsaturated LPAs strongly induce VSMC dedifferentiation via the coordinated activation of the extracellular signal-regulated kinase(More)
OBJECTIVE The aims of this study were to characterize the symmetrical features of patients with facial deformities and to suggest a classification system for facial asymmetry based on 3-dimensional-computed tomography (3D-CT) evaluation. STUDY DESIGN Preoperative CT images were investigated for 49 patients with maxillofacial deformities. Asymmetry indices(More)
Neural stem cells (NSCs) were directly induced from mouse fibroblasts using four reprogramming factors (Oct4, Sox2, Klf4, and cMyc) without the clonal isolation of induced pluripotent stem cells (iPSCs). These NSCs gave rise to both neurons and glial cells even at early passages, while early NSCs derived from clonal embryonic stem cells (ESCs)/iPSCs(More)
Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process of tumor growth. To clarify the roles(More)
This paper reports the results of a phonetic experiment investigating Korean 'denasalization', specifically, on the amount of nasality as a function of different prosodic contexts. The variation in nasal energy of onset nasal consonants of 5 subjects, from regions where the tendency of ‘denasalization’ is reported to be strong (Kyunggi-do: 3 subjects) and(More)