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In this paper, we propose a novel method for semi-supervised learning, called logistic label propagation (LLP). The proposed method employs the logistic function to classify input pattern vectors, similarly to logistic regression. To cope with unlabeled samples as well as labeled ones in the semi-supervised learning framework, the logistic functions are(More)
Support Vector Machines (SVMs), though accurate, are still difficult to solve large-scale applications, due to the computational and storage requirement. To relieve this problem, we propose RANSAC-SVM method, which trains a number of small SVMs for randomly selected subsets of training set, while tuning their parameters to fit SVMs to whole training set.(More)
This paper discusses Japanese efforts related to critical infrastructure protection, including several case studies to clarify the risk components and countermeasures. An interdependency modeling framework that combines the inoperability input-output model (IIM) for economic in-terdependencies and Bayesian networks for operational dependencies is presented.(More)
Recruitment of RAD18 to stalled replication forks facilitates monoubiquitination of PCNA during S-phase, promoting translesion synthesis at sites of UV irradiation-induced DNA damage. In this study, we show that RAD18 is also recruited to ionizing radiation (IR)-induced sites of DNA double-strand breaks (DSBs) forming foci which are co-localized with 53BP1,(More)
Oxidative damages induced by a redox imbalance cause age-related changes in cells and tissues. Superoxide dismutase (SOD) enzymes play a major role in the antioxidant system and they also catalyze superoxide radicals (O2·-). Since the loss of cytoplasmic SOD (SOD1) resulted in aging-like phenotypes in several types of mouse tissue, SOD1 is essential for the(More)
Cu-Zn superoxide dismutase (Sod1) loss causes a redox imbalance as it leads to excess superoxide generation, which results in the appearance of various aging-related phenotypes, including skin atrophy. Noble metal nanoparticles, such as palladium (Pd) and platinum (Pt) nanoparticles, are considered to function as antioxidants due to their strong catalytic(More)