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Previous studies have suggested that calcium/calmodulin-dependent protein kinase IV (CaMKIV) functions as a positive regulator for memory formation and that age-related memory deficits are the result of dysfunctional signaling pathways mediated by cAMP response element-binding protein (CREB), the downstream transcription factor of CaMKIV. Little is known,(More)
In this paper, we propose a regularized Newton method without line search. The proposed method controls a regularized parameter instead of a step size in order to guarantee the global convergence. We demonstrate that it is closely related to the TR-Newton method when the Hessian of the objective function is positive definite. Moreover, it does not solve(More)