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  • Maiko Tanabe, Ichiro Ieiri, +9 authors Kenji Otsubo
  • Biology, Medicine
  • The Journal of pharmacology and experimental…
  • 2001 (First Publication: 1 June 2001)
  • To evaluate whether mutations in the human multidrug resistance (MDR)-1 gene correlate with placental P-glycoprotein (PGP) expression, we sequenced the MDR-1 cDNA and measured PGP expression byExpand
  • Harumi Takahashi, Grant R. Wilkinson, +12 authors Hirotoshi Echizen
  • Biology, Medicine
  • Pharmacogenetics and genomics
  • 2006 (First Publication: 1 February 2006)
  • Objective To investigate pharmacokinetic and pharmacodynamic factors associated with population differences in warfarin doses needed to achieve anticoagulation, in particular the possible involvementExpand
  • Kazuya Maeda, Ichiro Ieiri, +8 authors Yuichi Sugiyama
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • 2006 (First Publication: 1 May 2006)
  • OBJECTIVE Recent reports have shown that genetic polymorphisms in organic anion transporting polypeptide (OATP) 1B1 have an effect on the pharmacokinetics of drugs. However, the impact of OATP1B1*1bExpand
  • Eriko Shikata, Ichiro Ieiri, +5 authors Kenji Otsubo
  • Biology, Medicine
  • Blood
  • 2004 (First Publication: 4 December 2003)
  • We analyzed mutations of 7 vitamin K-dependent protein and cytochrome P450 2C9 genes in 45 patients and investigated whether any contribute to the large interpatient variability in the warfarinExpand