Kenji Okada

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BACKGROUND Recent studies worldwide have reported increasing numbers of adults diagnosed with Bordetella pertussis despite receiving childhood vaccinations. This study describes a pertussis outbreak at a university medical faculty campus and examines the effectiveness of diphtheria, tetanus, and pertussis (DTaP) vaccination completed during infancy in(More)
Haemophilus influenzae type b (Hib) and 7-valent pneumococcal (PCV7) vaccines both became recommended in Japan in 2010. In this study, cytokine production was investigated in peripheral blood mononuclear cells (PBMCs) cultures stimulated with diphtheria and tetanus toxoids combined with acellular pertussis vaccine (DPT), Hib, and PCV7 separately or(More)
UDP-glucuronosyltransferase 1A9 (UGT1A9) contributes to the glucuronidation of numerous drugs. Cynomolgus monkeys are regarded as experimental animals similar to humans in studies on safety evaluation and biotransformation for drug development. In this study, the similarities and differences in the enzymatic properties of UGT1A9 between humans and(More)
Since the multi-scale finite element analysis (FEA) requires large computation time, development of the parallel computing technique for the multi-scale analysis is inevitable. A parallel elastic/crystalline viscoplastic FEA code based on a crystallographic homogenization method has been developed using PC cluster. The homogenization scheme is introduced to(More)
In this paper, we examine robust feature extraction methods for automatic speech recognition (ASR) in noise-distorted environments. Several perceptual experiments have shown that the range between 1 and 10 Hz of modulation frequency band is important for ASR. Combining the coefficients of multi-resolutional Fourier transform to split the important(More)
Fiber diffraction dada from polymers are sufficiently different in kind and quantity from single crystal data as to warrant analyses with a different emphasis: refinement of competing molecular models where torsion angles and bond angles are the explicit variables rather than atomic coordinates. The first linked-atom least-squares (LALS) refinement program(More)