Kenji Nishioka

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BACKGROUND Therapeutic hypothermia (TH) is a standard strategy to reduce brain damage in post-cardiac arrest syndrome (PCAS) patients. However, it is unknown whether the target temperature should be adjusted for PCAS patients in different states. METHODS Participants in the J-PULSE-Hypo study database were divided into lower (32.0-33.5 °C; Group L) or(More)
Natural killer cell-mediated cytotoxicity (NKCC) is one of sev eral possible immune defense mechanisms that may protect against the development of solid-tumor métastases. We have demonstrated that in vitro NKCC can be significantly impaired by both surgical stress and progressive tumor burden. Female C57BL/6 mice received a hindfoot amputation under(More)
a-Difluoromethylornithine (DFMO) treatment has been shown to modify carcinogenesis in many experimental tumor models, including skin, breast, and colon. This study was designed to determine whether DFMO treatment can inhibit experimental mouse colon tumors after carcinogen treatment and whether an associated effect of DFMO on cell proliferation in colon(More)
BACKGROUND Primary aldosteronism (PA) is a most common cause of secondary hypertension. In PA, left ventricular hypertrophy (LVH) is more progressive than in any other cause of hypertension. Aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) are major subtypes of PA. However there is little information concerned with differences of(More)
  • Kensuke Umemura, Masao Noma, Kazuaki Yoshizumi, Yukihito Chayama, Masashi Higashi, Keiko Kimura +14 others
  • 2007
Background—Several studies have shown that both early and late effects of ischemic preconditioning (IPC) protect against myocardial injury after ischemic reperfusion. Methods and Results—The purpose of this study was to evaluate the late effects of IPC on endothelial function in humans. Late phase of IPC was induced by upper limb ischemia (cuff inflation of(More)
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