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  • Yutaka Kurebayashi, Shigenori E. Nagai, +9 authors Shigeo Koyasu
  • Biology, Medicine
  • Cell reports
  • 2012 (First Publication: 1 April 2012)
  • The PI3K-Akt-mTORC1 axis contributes to the activation, survival, and proliferation of CD4(+) T cells upon stimulation through TCR and CD28. Here, we demonstrate that the suppression of this axis byContinue Reading
  • Kentaro Tanaka, Kenji Ichiyama, +11 authors Akihiko Yoshimura
  • Biology, Medicine
  • Journal of immunology
  • 2008 (First Publication: 15 March 2008)
  • Suppressor of cytokine signaling 1 (SOCS1) is an important negative regulator for cytokines; however, the role of SOCS1 in Th17 differentiation has not been clarified. We generated T cell-specificContinue Reading
  • Yumiko Matsumura, Takashi Kobayashi, +9 authors Akihiko Yoshimura
  • Biology, Medicine
  • Journal of immunology
  • 2007 (First Publication: 15 August 2007)
  • Dendritic cells (DCs) induce immunity and immunological tolerance as APCs. It has been shown that DCs secreting IL-10 induce IL-10(+) Tr1-type regulatory T (Treg) cells, whereas Foxp3-positive TregContinue Reading
  • Tomohito Takimoto, Yu Wakabayashi, +12 authors Akihiko Yoshimura
  • Biology, Medicine
  • Journal of immunology
  • 2010 (First Publication: 15 July 2010)
  • Although it has been well established that TGF-beta plays a pivotal role in immune regulation, the roles of its downstream transcription factors, Smad2 and Smad3, have not been fully clarified.Continue Reading
  • Kenji Ichiyama, Takashi Sekiya, +8 authors Akihiko Yoshimura
  • Medicine, Biology
  • Immunity
  • 2011 (First Publication: 1 May 2011)
  • Transforming growth factor-β (TGF-β) has been shown to be required for Th17 cell differentiation via Smad-independent mechanisms. The molecular mechanism underlying this pathway remains to beContinue Reading