Kenichiro Katsura

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We determined the growth-active domains of milk-growth factor (MGF), human alpha-lactalbumin (HMLA) and human lysozyme (HMLZ), and their sequences. Fetal calf serum (FCS) showed inhibitors against proteases. The growth-stimulation of IMR90 cells in CG medium (free-serum) without FCS was induced in a dose-dependent manner up to 400 ng/ml of HMLA, HMLZ or(More)
This study aims to determine if erythromycin has neuroprotective effects against transient ischemia and oxygen-glucose deprivation (OGD) in cultured neuronal cells. Sprague-Dawley rats were subjected to middle cerebral artery occlusion for 90 min, followed by reperfusion. The animals received a subcutaneous single injection of erythromycin lactobionate (EM,(More)
The frequency of post-stroke depression (PSD) was evaluated in an ischemic stroke cohort four weeks after onset, and the relationship between self-rating depression scale (SDS)/and infarct size, number and location of the ischemic brain lesions was also studied. The effects of a newly developed antidepressant SSRI (selective serotonin reuptake inhibitor),(More)
The differentiation activity of milk growth factor (MGF, 200 ng/ml), which also has proliferative activity, was investigated in NT2/D1 cells relative to that of retinoic acid (RA, 10(-7) M). MGF suppressed the proliferation of NT2/D1 cells to the same extent as RA after cultivation for 2x4 days. MGF enhanced Fas expression in NT2/D1 cells and prevented the(More)
We report a 76-year-old man with paradoxical cerebral air embolism. He developed consciousness disturbance and left hemiparesis after a postural change in rehabilitation. CT showed multiple air densities within the right hemisphere. An echocardiography showed a large right-to-left (RL) shunt. We considered the reason to be that a small amount of air(More)
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