Kenichiro Iwamura

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Coagulation and vascular abnormalities were studied in 4 patients with Crow-Fukase syndrome (CFS or POEMS) to understand the pathophysiology. Fibrinogen, fibrinopeptide A, and thrombin-antithrombin complexes (TAT) increased in sera during active phase of CFS. In nerves of 2 untreated cases, the endothelium of small vessels was immunohistochemically stained(More)
A double-blind crossover trial was conducted of thyrotropin releasing hormone treatment in six patients with amyotrophic lateral sclerosis. Patients received 4 mg of thyrotropin releasing hormone intramuscularly daily during the two-week treatment period. Although three patients reported subjective improvement, objective evaluation failed to demonstrate(More)
In Japan, most cases of primary hepatocellular carcinoma are associated with liver cirrhosis. Therefore, we must carefully consider the occurrence of hepatocellular carcinoma in cases where liver cirrhosis can be diagnosed. Among 333 patients with liver cirrhosis in whom the clinical course was observed for at least one year after initial diagnosis in the(More)
The pattern of serum cholinesterase (ChE) isozyme appeared to be characteristically abnormal in liver cirrhosis and hepatoma. In liver cirrhosis an abnormal fast moving peak was observed in 92.5% of fifty three patients studied. Further, diminishing activities of ChE 3 and 4, accompanied by an emergence of weak bands with unusual rates of flow, were noted(More)
A method for separation of serum (pseudo) cholinesterase isozymes was studied in order to take advantage of it for clinical research. By employing modifications on a previously reported method, analytical time was shortened to a half (1.5 days) of the original method without abolishing qualitative and quantitative accuracy. Thus, the present method(More)
For a long time, it has been assumed that stagnation of active estrogens in the blood gives rise to liver injury and causes a severe inflammatory process in the liver as well as affecting the clinical course of chronic aggressive hepatitis in women. During reproductive years, estrogen production, as gaged by the values of urinary excretion, follows a cyclic(More)
Although the pathogenesis of liver cirrhosis is complex and not clearly understood, it can be assumed that the morphologic changes in the liver do not occur suddenly in a short space of time and that the morphogenesis goes on insidiously. Therefore, the physician discovers liver cirrhosis coincidentally during evaluation of some other unrelated disease in(More)
No matter whether it is the B type or non-A, non-B type, chronic infection with the hepatitis virus often causes chronic hepatitis, which may ultimately lead to cirrhosis and even hepatocellular carcinoma. From an epidemiological point of view, it was considered that tattooing might be an important mode of transmission of hepatitis virus through tattoo(More)