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Comparative simulations between isotropic and anisotropic computer heart models were conducted to study the effects of myocardial anisotropy on the excitation process of the heart and on body surface electrocardiogram. The isotropic heart model includes atria, ventricles, and a special conduction system, and is electrophysiologically specified by parameters(More)
To elucidate the clinical characteristics of patients with right bundle branch block and ST elevation in the right precordial leads, a prospective follow-up study was made in 63 registered patients, including 17 with a history of ventricular fibrillation (VF) and 14 with a history of syncope. The prevalence of coved type ST elevation was significantly(More)
OBJECTIVES We sought to determine the prevalence of right bundle branch block (RBBB) and ST segment elevation in the working Japanese population, as well as the event rate during a three-year prospective follow-up period. BACKGROUND A poor prognosis of RBBB and ST segment elevation has been reported in Europe and South America, even in asymptomatic(More)
Recent studies have reported the relation between Torsade de Pointes (TdP) and midmyocardial (M) cell function associated with long QT syndrome. To investigate this relation, we conducted a simulation study with a three-dimensional (3D) heart model incorporating M cells in the anterolateral areas of the model. Parameters of premature cycle-length dependent(More)
The antifibrillatory action of antiarrhythmic drugs, classified on the basis of their effects on ventricular fibrillation threshold (VFT), was investigated. The relation between drug action and cardiac excitability, orthodromic/antidromic conduction through Purkinje fibers and ventricular muscle and the restitution of premature action potential duration was(More)
A circumferential profile analysis with a two-dimensional polar representation of thallium(Tl)-201 myocardial single photon emission computed tomograms (SPECT) is an objective and quantitative method to evaluate myocardial infarction (MI). However, the diagnostic capability depends on the normal range of thallium distribution. Therefore, the quantitative(More)
SUMMARY In 12 patients with nocturnal angina pectoris, all-night continuous polygraphic recordings were made, including electroencephalogram, elec-trooculogram, electromyogram, impedance pneumogram and electro-cardiogram, and ECG was analyzed in relation to heart rate and sleep stages. Out of 58 episodes of ischemic ST,T changes which were recorded with the(More)
Supraventricular tachycardias with the Wolff-Parkinson-White (WPW) syndrome have been successfully simulated using a newly developed simulation system. The heart model, including atria and ventricles, was constructed of about 50,000 discrete elements (model cells) in three dimensions with 1.5-mm spatial resolution. The model cells covered all of the types(More)