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OBJECTIVE To evaluate the efficacy of a 10-mg dose of midodrine 3 times per day in improving blood pressure (BP) and ameliorating symptoms of orthostatic hypotension in patients with neurogenic orthostatic hypotension. Midodrine hydrochloride, an alpha-agonist, could improve orthostatic BP by increasing vasomotor and venomotor tone. DESIGN/METHODS A total(More)
OBJECTIVE To determine the best therapeutic strategy for the use of midodrine in patients with neurogenic orthostatic hypotension (NOH). BACKGROUND Midodrine is a peripherally acting alpha-adrenergic agonist useful in the treatment of NOH. However, neither the most effective dosage of midodrine nor the required frequency of administration is established.(More)
In searching for strong homologies between multiple nucleic acid or protein sequences, researchers commonly look at fixed-length segments in common to the sequences. Such homologies form the foundation of segment-based algorithms for multiple alignment of protein sequences. The researcher uses settings of "unusualness of multiple matches" to calibrate the(More)
Given two independent sequences of letters, we seek the probability distribution of the length of the longest matching word. This word can be in different positions in the two sequences and we consider both perfect and nearly perfect matching. We derive bounds and approximations for the probability and compare them with other bounds and approximations. The(More)
OBJECTIVE To investigate the clinicopathologic features, diagnosis, treatment and prognosis of uterine mullerian adenosarcoma. METHODS The clinicopathological data of 9 cases of uterine mullerian adenosarcoma in PUMC hospital from January 2003 to February 2009 were retrospectively analyzed. RESULTS There were 6 uterine endometrial adenosarcomas and 3(More)
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