• Publications
  • Influence
HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.
TLDR
It is reported that histone deacetylase 6 (HDAC6) sequentially deacetyates and ubiquitinates MSH2, leading to MSH 2 degradation, which significantly reduces cellular sensitivity to DNA-damaging agents and decreases cellular DNA mismatch repair activities by downregulation of MSH1. Expand
Extracellular Signal-regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration*
TLDR
It is revealed for the first time that ERK binds to and phosphorylates HDAC6 to promote cell migration via deacetylation of α-tubulin, suggesting thatHDAC6-mediated cell migration could be governed by EGFR-Ras-Raf-MEK-ERK signaling. Expand
Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells
TLDR
It is suggested that HDAC6 is positively associated with cisplatin resistance in NSCLC and revealed as a potential novel therapeutic target for platinum refractory NSCLc. Expand
Ubiquitin-specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutS Homolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage*
TLDR
It is reported that ubiquitin-specific peptidase 10 (USP10) interacts with and stabilizes MSH2 and suggests a novel USP10-MSH2 pathway regulating DNA damage response and DNA mismatch repair. Expand
A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes
TLDR
This study is the first example of using a systems genetics approach to successfully identify novel susceptibility genes for aggressive prostate cancer using the C57BL/6-Tg(TRAMP)8247Ng/J mouse model. Expand
HDAC6-Dependent Functions in Tumor Cells: Crossroad with the MAPK Pathways.
TLDR
The literature on HDAC6 and MAPK pathways is summarized, the interaction between HDAC 6 and the ERK-MAPK signaling cascade is emphasized, and the roles of EGFR and Ras are reported to modulate. Expand
Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.
TLDR
Crossing a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice demonstrates how well-characterized genetic variation in mice can be harnessed in conjunction with systems genetics approaches to identify and characterize germline modifiers of human disease processes. Expand
Protective effect of inositol hexaphosphate against UVB damage in HaCaT cells and skin carcinogenesis in SKH1 hairless mice.
TLDR
Inositol hexaphosphate (IP6), an antioxidant, is a naturally occurring polyphosphorylated carbohydrate that has shown a strong anticancer activity in several experimental models and it is found that IP6 counteracts the harmful effects of UVB irradiation and increases the viability and survival ofUVB-exposed cells. Expand
GNL3 and SKA3 are novel prostate cancer metastasis susceptibility genes
TLDR
This novel approach demonstrates how mouse models can be used to identify metastasis susceptibility genes, and gives new insight into the molecular mechanisms of fatal PC. Expand
Effect of inositol hexaphosphate on the development of UVB-induced skin tumors in SKH1 hairless mice.
TLDR
Results show that IP6 has an antiphotocarcinogenic effect and can protect against UVB-induced tumor formation, and significantly decreased tumor incidence and tumor multiplicity. Expand
...
1
2
...