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Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in a latent formExpand
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.
Examination of the in vivo fate of effector cells revealed that CD25(lo) cells, which are relatively less sensitive to IL-2, preferentially upregulate CD127 and CD62L and give rise to functional long-lived memory cells, and data support the hypothesis that prolongedIL-2 signals during priming promote terminal-effector differentiation. Expand
Long term culture of tumour-specific cytotoxic T cells
An adaptation of this method which allows the long term culture of antigen-selected cytotoxic T cells which continue to demonstrate high levels of syngeneic tumour-specific cytotoxicity after more than 4 months in culture is described. Expand
Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response
The integrated model yields quantitative, experimentally validated predictions for the manipulation of Treg suppression, the mechanism enforcing, at the systems level, the specific suppression of survival signals for weakly activated Teff cells but not for strongly activated cells. Expand
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
The effects of IL-2 therapy during the expansion, contraction and memory phases of the T-cell response in lymphocytic choriomeningitis virus (LCMV)–infected mice were examined to determine whether opposing results are due to IL-1 acting differently on T cells depending on their stage of differentiation. Expand
Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.
Findings support the principal role of IL-2R alpha to deliverIL-2 to the signaling complex and act as regulator of signal transduction. Expand
Edward Jenner and the Small Pox Vaccine
The vaccine that Jenner used, which decreased the prevalence of Small Px worldwide in his own time, and later was used to eradicate Small Pox altogether, is discussed in light of recent data. Expand
PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells.
Combined IL-2 therapy and PD-L1 blockade merits consideration as a regimen for treating human chronic infections and cancer, with striking synergistic effects in enhancing virus-specific CD8+ T cell responses and decreasing viral load. Expand
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2
A microbiota- and IL-1β-dependent axis of IL-2 production by group-3 innate lymphoid cells is shown in a mouse model to be necessary to maintain immunological homeostasis and regulatory T cells in the small intestine. Expand
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor
It is demonstrated that anti-Tac suppresses TCGF induced proliferation of T cells and blocks binding of radiolabelled TCGF to cells from a cloned human continuous T-cell line. Expand