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Although epidermal growth factor receptor (EGFR) is particularly important in the pathogenesis of head and neck squamous cell carcinomas (HNSCCs), conflicting data have been reported on the correlation between EGFR copy number and survival and the association between EGFR copy number and protein expression. Anatomical site of the tumour in HNSCCs may likely(More)
The prognosis of oral squamous cell carcinoma (OSCC) is significantly dependent on the existence of cervical lymph node metastasis (LNM), with the overall survival rate being much lower in patients with LNM. Primary causes and molecular mechanisms of LNM are still largely unclear. We hypothesized that factors related with(More)
Age is known to be a major risk factor for adverse postoperative cognitive dysfunction after cardiac surgery. We conducted this study to determine if jugular venous oxygen saturation (SjvO2) differed during mild hypothermic (32°C) and normothermic cardiopulmonary bypass (CPB) in elderly patients. Sixty patients aged over 70 years who underwent elective(More)
The use of volatile anesthetics has been reported to alter cerebrovascular carbon dioxide (CO2) reactivity. We examined the comparative effects of sevoflurane versus isoflurane on cerebrovascular CO2 reactivity in 40 patients with diabetes mellitus. Anesthesia was maintained with either 1.0 minimum alveolar anesthetic concentration of sevoflurane or 1.0(More)
STUDY OBJECTIVE To examine the age-related difference between elderly and young patients in the effect of propofol on cerebrovascular carbon dioxide (CO(2)) reactivity. DESIGN Prospective controlled study. SETTING University hospital. PATIENTS Elderly (older than 70 years, n = 13) and young patients (younger than 25 years, n = 13) scheduled for(More)
STUDY OBJECTIVE To examine whether patients with previous stroke have impaired cerebrovascular carbon dioxide (CO2) reactivity when receiving propofol anesthesia. DESIGN Prospective, controlled study. SETTING University hospital. PATIENTS 34 consecutive patients, 17 of whom had previous stroke and were scheduled for elective cardiac surgery, and 17(More)
STUDY OBJECTIVE To characterize the effects of antihypertensive medications on cardiac function using transthoracic echocardiography during electroconvulsive therapy (ECT). STUDY DESIGN Randomized, double-blind study set at a university hospital. PATIENTS 30 American Society of Anesthesiologists (ASA) physical status I and II patients undergoing ECT. (More)
The use of volatile anesthetics is reportedly related to altered cerebrovascular carbon dioxide (CO2) reactivity. We examined the comparative effects of sevoflurane versus isoflurane on cerebrovascular CO2 reactivity in patients with previous stroke. Twenty-four patients with previous stroke and 20 patients without previous stroke (serving as controls) were(More)
Although chromosomal instability (CIN) has been detected in many kinds of human malignancies by means of various methods, there is no practical assessment for small clinical specimens. In this study, we evaluated CIN in fine-needle aspiration (FNA) biopsied oral squamous cell carcinomas (SCCs) using fluorescence in situ hybridization (FISH) analysis, and(More)
BACKGROUND Cyclin D1 (CCND1) and p16 alterations have been detected in oral squamous cell carcinomas (SCCs), suggesting that abnormalities of these genes may play an important role in the genesis or progression of oral SCCs and serve as independent prognostic indicators. The detection of CCND1 and p16 aberrations using a simple and sensitive method would be(More)