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YM-254890 analogues, novel cyclic depsipeptides with Galpha(q/11) inhibitory activity from Chromobacterium sp. QS3666.
The structure elucidation and biological activity of novel YM-254890 analogues and semi-synthetic derivatives are described, indicating that the acyl beta-HyLeu residue plays an important role in activity and also that the alpha,beta-unsaturated carbonyl group of the N-MeDha residue is not critical to activity.
YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge II. Structure elucidation.
Two new antibacterial substances that have activity against drug-resistant bacteria produced by Bacillus cereus QN03323 are revealed, containing the cyclic thiopeptides containing thiazole and pyridine moieties, and several unusual amino acids.
YM-254890, a novel platelet aggregation inhibitor produced by Chromobacterium sp. QS3666.
A novel platelet aggregation inhibitor, YM-254890, was isolated from the culture broth of strain QS3666 and inhibited ADP-induced platelets aggregation in human platelet-rich plasma with an IC50 value below 0.6 microM by blocking the P2Y1 receptor-signal transduction pathway.
YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological
Two novel antibiotics were found in the culture broth of Bacillus cereus QN03323 which was isolated from the marine sponge Halichondria japonica and exhibited potent antibacterial activities against staphylococci and enterococci including multiple drug resistant strains.
YM-215343, a novel antifungal compound from Phoma sp. QN04621.
YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus and showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 microg/ml.
Novel Malonamide Derivatives as αvβ3 Antagonists. Syntheses and Evaluation of 3-(3-Indolin-1-yl-3-oxopropanoyl)aminopropanoic Acids on Vitronectin Interaction with αvβ3
: In attempt to find novel integrin alphavbeta3 antagonists, we selected SC65811 and its guanidine analogue (1) as lead compounds. Modification of the glycine part of SC65811 led to a new series of
YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis
A novel cytotoxic cyclic peptide isolated from the cultured mycelium of Streptomyces nobilis JCM 4274 and the absolute configuration of the amino acid residues in YM-216391 was determined by Marfey's analysis and chiral HPLC analysis of its acid hydrolysate.
YM-202204, a new antifungal antibiotic produced by marine fungus Phoma sp.
This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells.
Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. II. Structural elucidation.
The physico-chemical properties and structural elucidation of gerfelin (1a) are described, which is readily soluble in methanol and acetone, but insoluble in chloroform and acetonitrile.
YM-92447 (spinosulfate A), a neuraminidase inhibitor produced by an unidentified pycnidial fungus.
This research attacked the mode of recognition of E.coli as a “spatially aggregating substance” and found that E. coli can be sexually transmitted through contact chemoreception and “gene recognition” is a natural “corresponding pathway” to HIV.