Ken - ichi Honma

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An autofeedback loop associated with transcription of clock gene(s), Per(s), is generally accepted as the molecular machinery of circadian rhythm generation, in which CLOCK/BMAL act as positive regulators and PER/CRY as negative ones. We show here an autofeedback loop of Dec1 encoding a basic helix-loop-helix transcription factor: CLOCK/BMAL increased the(More)
The circadian clock in mammals is located in the hypothalamic suprachiasmatic nucleus. At the core of the clock are molecular autofeedback loops associated with clock gene transcription. However, the mechanisms of circadian signal transduction are basically unknown. A recent report by Ikeda et al. provides new insights into the intracellular signaling(More)
1. Santoro, B. & Tibbs, G. R. The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels. Ann. NY Acad. Sci. 868, 741–764 (1999). 2. DiFrancesco, D. Pacemaker mechanisms in cardiac tissue. Annu. Rev. Physiol. 55, 455–472 (1993). 3. Pape, H. C. Queer current and pacemaker: the hyperpolarization-activated cation current in(More)
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