Ken-ichi Fukuda

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This review summarizes clinical application of adenosine and adenosine 5′-triphosphate (ATP) in pain conditions. Investigations have been performed in patients with acute perioperative pain or chronic neuropathic pain treated with intravenous adenosine or ATP, or intrathecal adenosine. Characteristic central adenosine A1 receptor-mediated pain-relieving(More)
By allowing reconstruction of compromised occlusion, dental implants contribute to an improvement in quality of life (QOL) and diet. Injury to a nerve during such treatment, however, can result in a sudden decline in QOL. And once a nerve has been injured, the chances of a full recovery are slim unless the damage is only slight. If such damage causes(More)
BACKGROUND Although a number of studies have investigated the association of the OPRM1 A118G polymorphism with pain response, a consensus has not yet been reached. METHODS The authors searched PubMed, EMBASE, and the Cochrane Library to identify gene-association studies that explored the impact of the OPRM1 A118G polymorphism on postoperative opioid(More)
PURPOSE The purpose of the present study was to determine whether intravenous sedation during dental implant surgery contributed to stabilization of hemodynamics. MATERIALS AND METHODS Two hundred fifty-five consecutive patients treated with dental implants were randomly assigned to receive either intravenous sedation with local anesthesia (sedation(More)
No study has been performed on the analgesic effect of adenosine 5′-triphosphate (ATP) on postherpetic neuralgia (PHN). We conducted an open-label trial of ATP in patients with PHN, and compared ATP with ketamine and lidocaine. Twelve patients with PHN were studied. On separate days, ketamine (0.3 mg·kg−1), lidocaine (2 mg·kg−1), and ATP (100 µg·kg−1·min−1(More)
Chronic orofacial pain is often refractory to conventional pain therapies. We conducted an open-label study to determine whether adenosine 5′-triphosphate (ATP) could alleviate chronic intractable orofacial pain, and if so, which type of pain could respond to ATP. In 8 and 16 patients with non-neuropathic and neuropathic intractable orofacial pain,(More)
We report a case of myofascial pain syndrome (MPS), manifested as nonodontogenic mandibular molar pain referred from the masseter muscle, relieved by a combination of trigger point injection (TPI) and stellate ganglion block (SGB). The patient was a 32-year-old woman who had experienced cold hypersensitivity in the right third mandibular molar 2 months(More)
the lateral site of the right leg as well as the dorsal and plantar sites of the right foot. The patient was initially treated at a dermatology clinic with oral valaciclovir (an antiviral agent) and diclofenac (an anti-inflammatory agent), and subsequently, with diclofenac alone for several weeks. Within a month of its onset, the pain in the leg and the(More)
We experience individual differences in pain and sensitivity to analgesics clinically. Genetic factors are known to influence individual difference. Polymorphisms in the human OPRM1 gene, which encodes the μ-opioid receptors, may be associated with the clinical effects of opioid analgesics. The purpose of this study was to determine whether any of the 5(More)
In contrast to reports on the classical laryngeal mask airway (classical LMA; CLMA), no report has calculated the 50% and 95% effect-site concentrations (EC50 and EC95, respectively) of propofol required for flexible LMA (FLMA) insertion. This study was designed to determine the EC50 and EC95 of propofol for FLMA insertion, using probit analysis, and to(More)