Ken R Page

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Both placental system A activity and fetal plasma cortisol concentrations are associated with intrauterine growth retardation, but it is not known if these factors are mechanistically related. Previous functional studies using hepatoma cells and fibroblasts produced conflicting results regarding the regulation of system A by cortisol. Using the b30 BeWo(More)
We report a case of Waterhouse-Friderichsen syndrome associated with group A streptococcus (GAS) toxic shock syndrome in a previously healthy man. The patient presented with neck pain and fevers of 2 days' duration. Computed tomography of the neck revealed a mass in the retropharyngeal space, suggesting an abscess. Despite prompt treatment with appropriate(More)
RPR127963 demonstrates an excellent pharmacokinetic profile in several species and was found to be efficacious in the prevention of restenosis in a Yucatan mini-pig model upon oral administration of 1-5 mg/kg. The in vitro selectivity profile and SAR of the highly optimized PDGF-R tyrosine kinase inhibitor are highlighted.
BACKGROUND PF-04965842 is an oral Janus Kinase 1 inhibitor being investigated for treatment of plaque psoriasis. OBJECTIVES To evaluate the efficacy, safety and tolerability of PF-04965842 in patients with moderate to severe plaque psoriasis. METHODS Patients in this phase 2, placebo-controlled study (NCT02201524) were randomised to receive placebo, 200(More)
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