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Acknowledgements During the last three years, my work has beneeted greatly from discussions with where I learnt the nal tools needed for this research. I hope that the ideas in this dissertation will only be used towards peaceful ends. This is the second edition of my thesis. Some typographical errors have been corrected, and a small number of clariications(More)
The Bayesian framework for model comparison and regularisation is demonstrated by studying interpolation and classification problems modelled with both linear and non–linear models. This framework quantitatively embodies ‘Occam’s razor’. Over–complex and under– regularised models are automatically inferred to be less probable, even though their flexibility(More)
Celecoxib, a selective inhibitor of cyclooxygenase-2 (Cox-2), was efficacious in clinical prevention trials of patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer. To identify as yet poorly defined molecular determinants of celecoxib efficacy, a multidimensional serum fractionation approach was used coupled with nanospray(More)
This paper describes the motivation for, and methodology behind the creation of ELSST (European Language Social Science Thesaurus), a broad-based multilingual thesaurus for the social sciences. The thesaurus was produced by the UK Data Archive (UKDA) as part of the EU-funded LIMBER (Language Independent Metadata Browsing of European Resources) project and(More)
Escherichia coli is a routinely used microbiological indicator of water quality. To determine whether holding time and storage conditions had an effect on E. coli densities in surface water, studies were conducted in three phases, encompassing 24 sites across the United States and four commonly used monitoring methods. During all three phases of the study,(More)
Hubel and Wiesel (1962) rst distinguished \simple" from \complex" cells in visual cortex, and proposed a processing hierarchy in which rows of LGN cells are pooled to drive oriented simple cell subunits, which are pooled in turn to drive complex cells. Though parsimonious and highly in uential, the pure hierarchical model has since been challenged by(More)
This thesis describes a new approach to conformal field theory. This approach combines the method of coadjoint orbits with the algebraic structures of resolutions and chiral vertex operators to give a construction of the correlation functions of conformal field theories in terms of geometrically defined objects. The coadjoint orbit method is used to(More)
c ©2001, 2008 by Kenneth Miller. This work is licensed under the Creative Commons AttributionNoncommercial-Share Alike 3.0 United States License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/us/ or send a letter to Creative Commons, 171 Second Street, Suite 300, San Francisco, California, 94105, USA. Current(More)