Ken McDonald

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AIM To assess the effects of oleic acid treatment on subcellular distribution of indium gallium phosphide-zinc sulfide (InGaP/ZnS) nanoparticles in microglia and astrocytes. MATERIALS & METHODS The extent of colocalization between the nanoparticles and organelles was assessed by confocal microscopy, spectrofluorometry and cell sorting. RESULTS Cell(More)
Recent studies suggest that immature, core-glycosylated DeltaF508-CFTR [the predominant mutant form of the CFTR (cystic fibrosis transmembrane conductance regulator)] can reach the plasma membrane under some conditions. In the present study we investigated this possibility since it has implications for understanding how therapeutics rescue the trafficking(More)
Recently, significant advances have been made in the management of many cardiovascular diseases. However, there remains a major concern that the problem of heart failure continues to grow, and that despite more effective therapies, this syndrome will continue to produce significant morbidity and place an ever increasing strain on health care resources.1,2(More)
In many European countries, patients with heart failure (HF) are treated according to specific management programs. The key players are the HF cardiologists and the HF nurses, and they are supported by a number of other important players. The objectives of the HF team are to help verify the diagnosis, optimize treatment, and inform and educate the patients(More)
A conceptual architecture study is under way to address the problem of getting the most scientific value from the large volumes of Earth and space science data that NASA expects to accumulate in the future. This involves efficient storage and access, but goes beyond that to facilitate intelligent data understanding and utilization through modeling realistic(More)
An 18-year-old female was an unrestrained, front seat, passenger in a car involved in a head-on collision with a heavy goods vehicle. The car was estimated to be travelling at 110 km/h. The patient was ejected through the front windscreenandwas foundbyemergency services 30 mfromthecar. Initial management was according to advanced trauma life support(More)
OBJECTIVE Extracorporeal membrane oxygenation within CPR (ECPR) may improve survival for refractory out-of-hospital cardiac arrest (OHCA). We developed a prehospital, emergency department (ED), and hospital-based clinical and educational protocol to improve the key variable of time-to-ECPR (TTE). METHODS In a single urban health region we involved key(More)
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