Ken M. Madden

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The study of atherogenesis in humans has been restricted by the limited availability and brief in vitro life span of plaque smooth muscle cells (SMCs). We describe plaque SMC lines with extended life spans generated by the expression of the human papillomavirus (HPV)-16 E6 and E7 genes, which has been shown to extend the life span of normal adult human(More)
I am pleased to introduce the third online issue of the Canadian Geriatrics Journal. This issue has a number of papers on a range of topics including neuropsychology, telemedicine, and the history of a prominent Canadian geriatrics research prize. Why is the Kaufman named the Kaufman? This is not a koan but the topic of a paper by Dr. Hogan (University of(More)
INTRODUCTION To describe changes in workplace physical activity, and health-, and work-related outcomes, in workers who transitioned from a conventional to an 'activity-permissive' workplace. METHODS A natural pre-post experiment conducted in Vancouver, Canada in 2011. A convenience sample of office-based workers (n=24, 75% women, mean [SD] age = 34.5(More)
Extracellular concentrations of excitatory amino acids increase substantially within cerebral tissue beds exposed to ischaemic conditions. This leads to excessive stimulation of N-methyl-D-aspartate (NMDA) receptors, a major cerebral excitatory neurotransmitter receptor that likely plays a critical role in the propagation of ischaemic injury in neurons.(More)
INTRODUCTION Type 2 diabetes mellitus (T2DM) affects more than 1.1 million Canadians aged ≥65 years. Group Medical Visits are an emerging health service delivery method. Recent systematic reviews show that they can significantly reduce glycated haemoglobin (HbA1c) levels, but Group Visits have not been evaluated within primary care. We intend to determine(More)
Weddell seals are polar predators that must partition their time between many behaviours, including hunting prey at depth and breathing at the surface. Although they have been well studied, little is known about how foraging behaviour changes when access to breathing holes is restricted, such as in the isolated-hole paradigm. The current study took(More)
Background Information: Limited research has suggested that rural residents are at increased risk of dementia. Objective: The objective of this study is to determine if rural residence is associated with dementia using both cross-sectional and prospective analyses. Methods: In 1991, 1763 community-dwelling adults aged 65+ participated in the Manitoba Study(More)