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Down syndrome (DS), or trisomy 21, is a common disorder associated with several complex clinical phenotypes. Although several hypotheses have been put forward, it is unclear as to whether particular gene loci on chromosome 21 (HSA21) are sufficient to cause DS and its associated features. Here we present a high-resolution genetic map of DS phenotypes based(More)
The first-degree relatives of probands with schizophrenia tend to have abnormal smooth pursuit eye tracking, even when the proband's smooth pursuit is normal. In order to account for this finding, we propose that schizophrenia and disturbed eye tracking are independent expressions of an underlying "latent" trait which is genetically transmitted. The data on(More)
Eye movement dysfunctions (EMDs), detectable during smooth pursuit, occur in a majority of schizophrenics and in 45% of their first-degree relatives. Previous data suggest that they represent a biologic marker for schizophrenia. To determine the mode of transmission of the schizophrenia-EMD complex, the eye movements of offspring of monozygotic and(More)
According to Webster the definition of Palladium is; " 1. (Greek Antiquity) Any statue of the goddess Pallas; esp., the famous statue on the preservation of which depended the safety of ancient Troy. 2. Hence: That which affords effectual protection or security; a safeguard; as, the trial by jury is the palladium of our civil rights.-Blackstone. " 1 In(More)
The classical polygenic theory of inheritance postulates a large number of genes with small, and essentially similar, effects. We propose instead a model with genes of gradually decreasing effects. The resulting phenotypic distribution is not normal; if the gene effects are geometrically decreasing, it can be triangular. The joint distribution of parent and(More)
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