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The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life
It is found that the telomeres shorten during ageing in a small freshwater teleost fish, the medaka, and that telomere maintenance through strong telomerase activity may be required for the characteristic lifelong continuous growth of this fish. Expand
Telomere lengths are characteristic in each human individual
Telomere lengths did not show clear correlation with tissue renewal times in vivo, but rather were characteristic for individuals. Expand
Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe
By using a minichromosome that has a complete set of centromere sequences, a fission yeast system is developed to detect gross chromosomal rearrangements (GCRs) that occur spontaneously and data suggest that Rad51 suppresses rearrangement ofCentromere repeats that result in isochromosomes formation. Expand
Changes of telomere length with aging
The quantitative fluorescence in situ hybridization (Q‐FISH) method for telomere measurement, using the original software program “Tissue Telo” is excellent for measuring telomeres lengths using tissue sections and PNA probes. Expand
Dietary patterns and stomach cancer among middle-aged male workers in Tokyo.
It is found that the V-shaped associations between dietary patterns and stomach cancer risk were appeared in the "meat" and "rice/snack" patterns, while the linear trend of these associations was statistically on borderline. Expand
Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage
The data indicate that telomere attrition and restoration are linked to growth and telomerase activity, and suggest that critical loss of telomeres homeostasis is associated with mortality in this animal. Expand
Sedative effect on humans of inhalation of essential oil of linalool:: Sensory evaluation and physiological measurements using optically active linalools
Abstract The sedative properties of linalool were examined using the optically active linalools, (R)-(−)-, (S)-(+)- and (RS)-(±)-forms. (R)-(−)-linalool with specific rotation of [α]D= −15.1° wasExpand
Identification of the thromboxane A2 receptor in hepatic sinusoidal endothelial cells and its role in Endotoxin‐induced liver injury in rats
Preadministration of both a cyclooxygenase inhibitor and a thromboxane A2 receptor antagonist attenuated the degree of endotoxininduced liver injury and indicated that the thromboxesized A2—throm boxane A1 receptor system in the hepatic sinusoids plays a significant role in the pathogenesis of endot toxin‐dependent liver damage. Expand
Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly
It is indicated that hMLH1 hypermethylation, concurrent with a lack of its protein expression, may play an important role in the development of medullary-type poorly differentiated colorectal adenocarcinomas in the elderly. Expand
Association of telomere shortening in myocardium with heart weight gain and cause of death
It is shown that telomeres in myocardial tissue become shortened with aging and heart disease, and that heart disease was associated with a gain of heart weight and telomere shortening in the myocardium. Expand