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Loss-of-function phenotypes often hold the key to understanding the connections and biological functions of biochemical pathways. We and others previously constructed libraries of short hairpin RNAs that allow systematic analysis of RNA interference-induced phenotypes in mammalian cells. Here we report the construction and validation of second-generation(More)
A 32 x 32 synchronous crossbar chip was designed in a 0.27pm CMOS technology for use in a high-speed network switch [I]. The crossbar chip uses 32 Asymmetric Serial Links [2][3] to achieve high speed at the interfaces and to reduce both power and area. The crossbar switch core is implemented with static CMOS multi-stage multiplexors with multicast(More)
Endophilin A1 is a homodimeric membrane-binding endocytic accessory protein with a high dimerization affinity. Its function has been hypothesized to involve autoinhibition. However, the autoinhibition mechanism, as well as the physicochemical basis for the high dimerization affinity of endophilin in solution, have remained unclear. In this contribution, we(More)
Continuous monitoring of variations in blood flow is vital in assessing the status of microvascular and macrovascular beds for a wide range of clinical and research scenarios. Although a variety of techniques exist, most require complete immobilization of the subject, thereby limiting their utility to hospital or clinical settings. Those that can be(More)