Learn More
Loss-of-function phenotypes often hold the key to understanding the connections and biological functions of biochemical pathways. We and others previously constructed libraries of short hairpin RNAs that allow systematic analysis of RNA interference-induced phenotypes in mammalian cells. Here we report the construction and validation of second-generation(More)
To maintain high performance across a wide variety of applications , the first-generation CELL processor [1], fabricated in 90nm SOI CMOS, requires hundreds of gigabits of aggregate I/O band-width. In this paper, circuit design considerations and the clock-ing architecture of the 6.4Gb/s/link, 12B (7 TX + 5 RX) parallel I/O, Redwood Rambus ASIC cell (RRAC),(More)
— This paper describes the design of a novel CMOS 2 Gb/s asymmetric serial link. The serial link is designed for systems that use high speed chip-to-chip communications. In such designs, power dissipation is a common problem, particularly when multiple serial links are required on one chip. The power arises primarily from the phase adjustment circuitry used(More)
The IST-project VIRTUE is now in its last year of a 3-year project. The overall aim of this project is to realise a real-time 3D videoconferencing system creating a convincing impression of immersive telepresence. The system design is completed and we are now able to present the final 3D videoconference station including the whole architecture of the(More)
Endophilin A1 is a homodimeric membrane-binding endocytic accessory protein with a high dimerization affinity. Its function has been hypothesized to involve autoinhibition. However, the autoinhibition mechanism, as well as the physicochemical basis for the high dimerization affinity of endophilin in solution, have remained unclear. In this contribution, we(More)