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Controlled delivery of paclitaxel from stent coatings using poly(hydroxystyrene-b-isobutylene-b-hydroxystyrene) and its acetylated derivative.
A poly(styrene-b-isobutylene-b-styrene) (SIBS) triblock polymer is employed as the polymer drug carrier for the TAXUS Express2 Paclitaxel-Eluting Coronary Stent system (Boston Scientific Corp.). It… Expand
Synthesis, characterization, properties, and drug release of poly(alkyl methacrylate-b-isobutylene-b-alkyl methacrylate).
Polyisobutylene (PIB)-based block copolymers have attracted significant interest as biomaterials. Poly(styrene-b-isobutylene-b-styrene) (SIBS) has been shown to be vascularly compatible and, when… Expand
Effect of ionizing radiation on the stability and performance of the TAXUS Express2 paclitaxel-eluting stent.
BACKGROUND The advent of drug-eluting stents has provided the interventional cardiologist an effective new tool in treating coronary restenosis. There remains, however, a small group of patients that… Expand
Controlled delivery of paclitaxel from stent coatings using novel styrene maleic anhydride copolymer formulations.
- R. Richard, Marlene C. Schwarz, Ken Chan, Nikolai Teigen, Mark W. Boden
- Medicine, Materials Science
- Journal of biomedical materials research. Part A
- 1 August 2009
The controlled release of paclitaxel (PTx) from stent coatings comprising an elastomeric polymer blended with a styrene maleic anhydride (SMA) copolymer is described. The coated stents were… Expand