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OBJECTIVE To determine if minocycline is an effective therapy for seropositive rheumatoid arthritis (RA) when used within the first year of disease. METHODS The Rheumatoid Arthritis Investigational Network enrolled 46 patients with RA of <1 year duration into a 6-month study of minocycline (100 mg twice daily) versus placebo. All patients were rheumatoid(More)
OBJECTIVE Rheumatoid arthritis (RA) causes substantial morbidity and mortality, and current treatments are suboptimal. Recent studies have demonstrated the short-term efficacy of minocycline in the treatment of patients with early RA. This study was undertaken to compare patients treated with conventional therapy in the early phase of their RA and those(More)
OBJECTIVE To compare the efficacy of minocycline with that of a conventional disease-modifying antirheumatic drug (DMARD), hydroxychloroquine, in patients with early seropositive rheumatoid arthritis (RA). METHODS Sixty patients with seropositive RA of <1 year's duration who had not been previously treated with DMARDs were randomized to receive(More)
Realistic models for node movement are essential in simulating mobile ad hoc networks. Many MANET scenarios are most realistically represented using group movement, but existing group movement models depict individual group members as independent actors moving randomly. For many scenarios however, group movement implies a common goal or orientation, and(More)
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