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Tumor necrosis factor α (TNF-α) receptor-associated factor 2 (TRAF2) regulates activation of the c-Jun N-terminal kinase (JNK)/c-Jun and the inhibitor of κB kinase (IKK)/nuclear factor κB (NF-κB) signaling cascades in response to TNF-α stimulation. Gene knockout studies have revealed that TRAF2 inhibits TNF-α-induced cell death but promotes oxidative(More)
Transendothelial impedance across an endothelial monolayer grown on a microelectrode has previously been modeled as a repeating pattern of disks in which the electrical circuit consists of a resistor and capacitor in series. Although this numerical model breaks down barrier function into measurements of cell-cell adhesion, cell-matrix adhesion, and membrane(More)
Running title: Caldesmon protects cytoskeletal-membrane integrity against adenovirus Abstract The cytoskeleton is critical to the viral life cycle. Agents like cytochalasin inhibit viral infections, but cannot be used for antiviral therapy because of their toxicity. We report the efficacy, safety and mechanisms by which gene delivery of human wild-type low(More)
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