Ken Blackwell

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Tumor necrosis factor α (TNF-α) receptor-associated factor 2 (TRAF2) regulates activation of the c-Jun N-terminal kinase (JNK)/c-Jun and the inhibitor of κB kinase (IKK)/nuclear factor κB (NF-κB) signaling cascades in response to TNF-α stimulation. Gene knockout studies have revealed that TRAF2 inhibits TNF-α-induced cell death but promotes oxidative(More)
Running title: Caldesmon protects cytoskeletal-membrane integrity against adenovirus Abstract The cytoskeleton is critical to the viral life cycle. Agents like cytochalasin inhibit viral infections, but cannot be used for antiviral therapy because of their toxicity. We report the efficacy, safety and mechanisms by which gene delivery of human wild-type low(More)
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