Kelwalin Dhanasarnsombut

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Polymorphic parasite antigens are known targets of protective immunity to malaria, but this antigenic variation poses challenges to vaccine development. A synthetic MSP-1 Block 2 construct, based on all polymorphic variants found in natural Plasmodium falciparum isolates has been designed, combined with the relatively conserved Block 1 sequence of MSP-1 and(More)
Transfusion transmitted malaria (TTM) in non-endemic countries is reduced by questioning blood donors and screening of donated blood. Conventional screening is performed by Indirect Fluorescence Antibody Test (IFAT). This method is manual and difficult to standardize. Here we study the diagnostic performance of a multiplex assay for detection of antibodies(More)
Background Antibodies mediate naturally acquired immunity to the asexual blood stages of human malaria. Merozoite surface antigen-specific antibodies inhibit the in vitro growth and development of the parasite P. falciparum, although the functional mechanisms of this inhibition are not fully understood. In this study, we investigated the functional(More)
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