Kelvin Manuel Piña Batista

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BACKGROUND Heparan sulfate proteoglycans (HSPGs) promote amyloid-β peptide and tau fibrillization in Alzheimer's disease (AD) and provide resistance against proteolytic breakdown. Heparanase (HPSE) is the only enzyme that cleaves heparan sulfate (HS). Heparanase 2 (HPSE2) lacks HS-degrading activity, although it is able to interact with HS with high(More)
Neurogenic stunned myocardium (NSM) is a clinicalpathological entity that presents with myocardial injury and dysfunction occurring after diverse types of acute brain injury; it results from imbalance of the autonomic nervous system which is typically secondary to subarachnoid haemorrhage. However, NSM may also be related to other central nervous system(More)
Glioblastoma multiforme (GBM), a highly aggressive brain cancer characterized by uncontrolled proliferation, resistance to cell death, angiogenesis, and vascular edema, remains one of the deadliest types of cancer. The subventricular zone (SVZ) harbors cells with great proliferative potential, and the microenvironment within the SVZ is permissive to growth(More)
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