Kelsey Mirkovic

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Enhanced glutamatergic neurotransmission in dopamine (DA) neurons of the ventral tegmental area (VTA), triggered by a single cocaine injection, represents an early adaptation linked to the more enduring effects of abused drugs that characterize addiction. Here, we examined the impact of in vivo cocaine exposure on metabotropic inhibitory signaling involving(More)
Two-pore domain K(+) (K(2P)) channels are thought to underlie background K(+) conductance in many cell types. The Trek subfamily of K(2P) channels consists of three members, Trek1/Kcnk2, Trek2/Kcnk10, and Traak/Kcnk4, all three of which are expressed in the rodent CNS. Constitutive ablation of the Trek1 gene in mice correlates with enhanced sensitivity to(More)
G protein-gated inwardly rectifying K(+) (Girk/K(IR)3) channels mediate the inhibitory effect of many neurotransmitters on excitable cells. Girk channels are tetramers consisting of various combinations of four mammalian Girk subunits (Girk1 to -4). Although Girk1 is unable to form functional homomeric channels, its presence in cardiac and neuronal channel(More)
Two-pore domain K(+) (K(2P)) channels underlie leak or background potassium conductances in many cells. The Trek subfamily of K(2P) channels, which includes Trek1/Kcnk2 and Trek2/Kcnk10 and has been implicated in depression, nociception, and cognition, exhibits complex regulation and can modulate cell excitability in response to a wide array of stimuli.(More)
  • Lydia A Kotecki, Kevin D Wickman, Nicole Wydeven, Nicole Victoria, Ezequiel Marron Fernandez De Velasco, Megan Tipps +9 others
  • 2015
i Dedication I would like to dedicate this to my family, without whom I could not have accomplished this. Your unwavering support and encouragement has been the cornerstone of my life. I can't thank you enough! To my Carini Family, Mary Carini and Jeff Martocci, for being exceptional role models and showing me the importance of lifelong learning. Thank you(More)
To explore the possible involvement of beta adrenoceptor antagonists in the previously observed anticonvulsive effect of swim stress, the mice were, prior to administration of convulsants, pre-treated with propranolol (a non-selective beta adrenoceptor antagonist), betaxolol (a selective beta-1 adrenoreceptor antagonist), or ICI 118,551 (a selective beta-2(More)
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