Kelsey A. Gregg

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Emerging resistance to "last-resort" polymyxin antibiotics in Gram-negative bacteria is a significant threat to public health. We identified the Acinetobacter baumannii NaxD deacetylase as a critical mediator of lipid A modification resulting in polymyxin resistance and demonstrated that naxD is regulated by the sensor kinase PmrB. This represents the first(More)
Adjuvant properties of bacterial cell wall components like MPLA (monophosphoryl lipid A) are well described and have gained FDA approval for use in vaccines such as Cervarix. MPLA is the product of chemically modified lipooligosaccharide (LOS), altered to diminish toxic proinflammatory effects while retaining adequate immunogenicity. Despite the virtually(More)
Work conducted in Biosafety Level 3 and Animal Biosafety Level 3 laboratories typically involves pathogens that are transmissible via the aerosol route that are capable of causing disease with moderate to severe illness, and can include work with species of animals that pose additional hazards to laboratory personnel. Mitigating the risk of exposure and(More)
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